73%Strong matchPATHOGEN X
82%21482% positive reviews, Very Positive across 214 reviews·Survival Horror · FPS
—







Prion Protein disrupted the functions of the human brain, turning individuals into wild, aggressive mutants. As part of a special military unit, you are the last hope. You are tasked with stopping the epidemic and containing the infected mutants. Destroy all mutants and keep running for your life.
Prion: Infection Prion is an FPS endless running game. Survive and try to catch your high score. Can you be successful? Ok then let's start running, welcome to the night. Don't forget that each level has its own scoreboard and there is also a global scoreboard. Story of Prion In the year 2025, the global landscape was forever altered by a clandestine biological cataclysm. A mysterious outbreak, birthed from the enigmatic Prion Protein, once heralded as a scientific marvel, now manifested as a nightmarish force. Its insidious influence twisted the delicate balance of human brain functions, transforming ordinary individuals into ferocious, unpredictable mutants. The contagion, a relentless tide, surged across continents, ensnaring a vast swath of the world's population in its sinister grip. Amidst the chaos, you emerge as a vital cog in the last bastion of defense—the cornerstone of humanity's dwindling hope. A member of an elite military unit specially forged to confront this existential threat head-on. Tasked with the Herculean mission of halting the relentless outbreak and wresting control from the clutches of the infected mutants, your journey unfolds as an arduous odyssey. The ever-evolving mutations within the afflicted mutants pose an escalating challenge, pushing the boundaries of your training and resilience. As each passing day witnesses the mutants' aggression intensify, the weight of the world rests heavily on the shoulders of your specialized unit. [06:20] At the epicenter of this harrowing narrative stands Captain Alex Mercer, the indomitable protagonist of our tale. A seasoned and courageous soldier, Mercer is not merely a warrior; he is the embodiment of humanity's last stand. Having undergone rigorous training and uniquely fortified with immunity against the insidious Prion outbreak, he becomes the linchpin in the battle to salvage what remains of our world. Mercer's mission, noble and perilous, is not merely about survival; it is a quest to reclaim the soul of humanity. The stakes are nothing short of global salvation as he plunges into the heart of the mutated maelstrom, armed not only with weapons but with the knowledge that his actions will determine the course of the world's destiny. The journey is fraught with danger, and every step forward unravels more about the sinister nature of the Prion Protein. Scientific revelations intertwine with the visceral struggle for survival, creating a narrative tapestry that weaves through the remnants of once-thriving cities and the desolation left in the wake of the pandemic. As Captain Mercer, you navigate a treacherous path, encountering not only mutated adversaries but the moral quandaries that arise in a world teetering on the brink of oblivion. The decisions made in the crucible of chaos shape not only the destiny of the protagonist but the fate of the entire human race. In this immersive journey, the boundaries between heroism and despair blur, and the line between savior and survivor becomes increasingly thin. Captain Alex Mercer is not just a soldier; he is the embodiment of resilience, a beacon of hope in a world plunged into the abyss. The Prion outbreak may have initiated the apocalypse, but it is the actions of one man that will determine whether humanity rises from the ashes or succumbs to the darkness that now threatens to consume it.
Steam data © 2026 Valve Corporation. Trademarks are property of their respective owners.
All matches
Finding similar games…
PATHOGEN XShares Shooter · FPS · First-Person , adds Survival Horror82% · 214 positive reviews73%Strong match—
PotentiaShares Action-Adventure · Shooter , adds Tactical68% · 345 positive reviews72%Strong match—
VLADiK BRUTALShares Action-Adventure · Shooter · FPS , adds Dystopian90% · 9k positive reviews68%Strong match—
Inner ChainsShares Action-Adventure · Shooter · FPS , adds Walking Simulator49% · 337 positive reviews70%Strong match—
FatalZoneShares Bullet Hell · Survival , adds Action Roguelike68% · 2k positive reviews72%Strong match—
The Living RemainShares Action-Adventure · Shooter · FPS , adds VR80% · 265 positive reviews69%Strong match—All matches
The best games like Prion: Infection are PATHOGEN X, Potentia, VLADiK BRUTAL, Inner Chains, and FatalZone.
Match on: filter matches for Prion: Infection by tag
Filters all matches
65%+Strong matches