68%Strong matchBig Pharma
78%1k78% positive reviews, Mostly Positive across 1k reviews·Management · Medical Sim
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Launch your painkiller, market it, and redefine the future of the pain industry. The leash of America is in new hands—yours! Make it crawl as you wish to form the world's first pharmaceutical republic. God Save America.
MAKE AMERICA SICK AGAIN
Steam
Build an opioid empire that expands from the streets to the schools of America.

MAKE AMERICA SICK AGAIN is a plague-like strategy game, meaning a mix of thought-strategy & realistic simulation where you manipulate people using various instruments of programming the society and using democracy as a tool to sell them your opioid, which provides the heavenly relief from every sin.
Lead the board of the newly created opioid by your pharma company to supply it to every household in the United States as per their needs, which you have to create (sometimes). Your final aim is to create a pharma theocracy out of this great nation now called the superstate of America. Inspired by the Great American Opioid Crisis, set from the early 90s to the late 2000s.
Launch a powerful painkiller 100x stronger than any other opioid exhibiting as a mild drug for low to severe pain relief, and supply it to every corner of the nation by using cunning marketing practices & democracy as your way forward to bring a pharmaceutical utopia.

The United States of America is your playground to bring freedom into people's bloodstream; do everything possible before they wake up.
Utilize the label "less than 1% get addicted" viciously, as this is your foremost propaganda tool based on 69 years of scientific research.

Maneuver things such as laws into your favor by placing mouthpieces in government offices to control every establishment. If they deny, provide them pain and then cure it with your painkiller.

Even after all your efforts, some small-time attorneys and whistleblowers and investigators who can't live without signaling honesty. You need to carefully tackle them; otherwise, they could become serious troublemakers for your company & drug.

A renounced approach by bringing in 1984's oligarchical rule and the theocratical framework of technofuedalism turned into pharmaceutical theocracy.
From the early 90s till today, the crisis has reported 1M+ deaths from overdose & counting. Many unreported cases are uncountable, and this time, take the responsibilities into your hands.
Steam data © 2026 Valve Corporation. Trademarks are property of their respective owners.
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