Find a co-op game with friends
Chemical Combat screenshot 1
Video 2
Chemical Combat screenshot 3
Chemical Combat screenshot 4
Chemical Combat screenshot 5
Chemical Combat screenshot 6
Chemical Combat screenshot 7
Chemical Combat screenshot 8

Games Like Chemical Combat

Sep 15, 2025·SigmoidDev·
100%6 user reviews · 6

Combine chemicals, prepare potions, and battle hordes of mythical monsters in this action-packed, chemistry-themed roguelike. You'll fight your way through a procedurally-generated science lab, exploding endless enemies and solving various puzzles, all to earn coins and upgrade your equipment.

Top matches

Match strength key:80+65+50+<50
Finding similar games…

About Chemical Combat

OVERVIEW 🔎

Chemical Combat is an action-packed, chemistry-themed roguelike in which choosing the right combination of chemicals is crucial. Armed with a diverse array of elements, you'll need to concoct potions to trigger a variety of deadly reactions in order to protect yourself from the numerous mythical monsters on the loose.

Set following a containment breach in a highly dangerous research facility, you'll battle your way through a maze of interconnected rooms, splashing enemies with explosive elixirs, solving various puzzles and minigames, and collecting coins to upgrade your equipment. Venture progressively deeper and tackle ever-tougher enemies with up to 36 unique upgrades, refining your tactics along the way.

ALCHEMY 🧪

With 16 elements to choose from and 30 unique reactions, there are numerous strategies you can adopt: from a deadly damage over time build to one focused on powerful explosions. Different enemies have different weaknesses, so plan accordingly...

Chemical Combat video 1

DUNGEONS 🗺️

With four unique biomes - monsters, magic, robots, and hell - and procedurally generated dungeons, each expedition will present you with a similar but distinct experience. Take on 16 different enemies, each with different mechanics and attacks, as well as 7 randomised minigames/puzzles for varied gameplay.

Chemical Combat video 2

UPGRADES ✨

Choose from the 36 upgrades available in the skill tree to find your optimal playstyle, whether it be aggressive, defensive, or utility-focused. Spend your hard-earned coins in any of the four quadrants - reaction, experimentation, exploration, and survivability - or on unlocking new elements in the quarry.

Chemical Combat video 3

COMING SOON 🔮

Chemical Combat is currently in early access, but don't worry - the game is perfectly functional and enjoyable in its current state! Over the coming months, I hope to add some of following features, but none are guaranteed:

•
Boss fights at the end of each floor
•
A few new floors (not 100% guaranteed)
•
Many new reactions (I have ideas for a new summoning playstyle)
•
Logbook entries containing lore, strategies, and more
•
Steam achievements (and potentially cosmetics, although this is less likely)
•
Permanent upgrades, purchasable with a new currency (depending on if the community likes this idea)
•
A revamped upgrade system with more specific paths
•
Shop rooms with collectable items and temporary buffs
•
Improved procedural generation with more varied layouts (this might be difficult to implement, so I'll see)

Steam data © 2026 Valve Corporation. Trademarks are property of their respective owners.

All matches

Similar games to Chemical Combat

Finding similar games…