







Games Like Pathogenic
Checking tracked store prices…
Store and price-comparison links open external sites. Prices and availability can change there.
Top matches
Match strength key:80+65+50+<50
Yet Another Zombie SurvivorsShares Top-Down Shooter · Bullet Hell · Action Roguelike , adds Zombies94% · 5k positive reviews$14.9971%Strong match
Plague Inc: EvolvedShares Difficult · Co-op · 2D , adds Outbreak Sim94% · 66k positive reviews$14.9973%Strong match
Genome GuardianShares Top-Down Shooter · Bullet Hell · Action Roguelike , adds Gun Customization93% · 659 positive reviews$11.9969%Strong match
Swarm GrinderShares Bullet Hell · Action Roguelike · 2D , adds Mechs78% · 1k positive reviews$7.9969%Strong match
Endoparasitic 2Shares Shooter · 2D , adds Survival Horror87% · 447 positive reviews$11.9972%Strong match
PATHOGEN XShares Shooter , adds Survival Horror82% · 214 positive reviews$9.9972%Strong match
FatalZoneShares Top-Down Shooter · Bullet Hell · Action Roguelike , adds Zombies68% · 2k positive reviews−10%$4.4966%Strong match
Freaky AwesomeShares Local Co-Op · Action Roguelike · Dungeon Crawler , adds Online Co-Op57% · 204 positive reviews$9.9965%Strong match
Match on: filter matches for Pathogenic by tag
Filters all matches
Pathogenic
SteamYou are a disease. Infect the human body as a lone pathogen in this cellular roguelike shooter. Collect organelles to evolve your parasite in a microscopic arms race against your host's immune system. Conquer a beautiful, procedurally generated world of tiny proportions.
About Pathogenic
CELLULAR COMBAT EVOLVED
In Pathogenic, you are the disease. Experience a visceral 2D roguelike twin-stick shooter where you play as a lone parasite fighting a desperate war against the immune system. Your goal is simple: infect and conquer your human host.

To survive, you must adapt. Hunt down enemy cells, rip out their organelles, and graft them onto your own body. Evolve from a simple cell into a complex engine of destruction. Create powerful, game-breaking builds and become the ultimate pathogen.
CREATE YOUR OWN PATHOGEN

Loot, graft, and assemble your parasite from dozens of unique organelles. Combine flagella for movement, mitochondria for power, secretors for ranged attacks, and spikes for melee combat. Chain organelle effects and discover powerful synergies to build an unstoppable disease vector.
FIGHT THE IMMUNE SYSTEM

Battle a diverse roster of enemies, from basic immune cells like macrophages and T cells to rival parasites such as tapeworms or protozoa. Formidable bosses are lurking deep within the host's organs.
METAPROGRESSION

Collect plasmid fragments to permanently upgrade your parasite's plasmid tree between runs. Each parasite will have it's own upgrade tree allowing for a range of builds to suit your preferred playstyle.
EXPLORE A MICROSCOPIC WORLD

Navigate the procedurally generated organic landscape of the human body. Travel through distinct biomes like the branching pathways of the lungs, the pulsating chambers of the heart, and the complex neural network of the brain.
FEEL THE ORGANIC ACTION
Our detailed, colorful world is powered by a soft-body physics simulation, giving every cell, enemy, and projectile a uniquely satisfying organic feel. The combination of hand-crafted design and procedural generation ensures endless variety - each run offers a fresh and challenging gameplay experience.
JOIN OUR COMMUNITY ON DISCORD

Steam data © 2026 Valve Corporation. Trademarks are property of their respective owners.