Games Like Pathogenic

About Pathogenic

CELLULAR COMBAT EVOLVED

In Pathogenic, you are the disease. Experience a visceral 2D roguelike twin-stick shooter where you play as a lone parasite fighting a desperate war against the immune system. Your goal is simple: infect and conquer your human host.

To survive, you must adapt. Hunt down enemy cells, rip out their organelles, and graft them onto your own body. Evolve from a simple cell into a complex engine of destruction. Create powerful, game-breaking builds and become the ultimate pathogen.

CREATE YOUR OWN PATHOGEN

Loot, graft, and assemble your parasite from dozens of unique organelles. Combine flagella for movement, mitochondria for power, secretors for ranged attacks, and spikes for melee combat. Chain organelle effects and discover powerful synergies to build an unstoppable disease vector.

FIGHT THE IMMUNE SYSTEM

Battle a diverse roster of enemies, from basic immune cells like macrophages and T cells to rival parasites such as tapeworms or protozoa. Formidable bosses are lurking deep within the host's organs.

METAPROGRESSION

Collect plasmid fragments to permanently upgrade your parasite's plasmid tree between runs. Each parasite will have it's own upgrade tree allowing for a range of builds to suit your preferred playstyle.

EXPLORE A MICROSCOPIC WORLD

Navigate the procedurally generated organic landscape of the human body. Travel through distinct biomes like the branching pathways of the lungs, the pulsating chambers of the heart, and the complex neural network of the brain.

FEEL THE ORGANIC ACTION

Our detailed, colorful world is powered by a soft-body physics simulation, giving every cell, enemy, and projectile a uniquely satisfying organic feel. The combination of hand-crafted design and procedural generation ensures endless variety - each run offers a fresh and challenging gameplay experience.