S.E.M.I. – Side Effects May Include... screenshot 1
S.E.M.I. Trailer_1
S.E.M.I. – Side Effects May Include... screenshot 3
S.E.M.I. – Side Effects May Include... screenshot 4
S.E.M.I. – Side Effects May Include... screenshot 5
S.E.M.I. – Side Effects May Include... screenshot 6
S.E.M.I. – Side Effects May Include... screenshot 7
S.E.M.I. – Side Effects May Include... screenshot 8

Games Like S.E.M.I. – Side Effects May Include...

Jan 23, 2026·Two Horn Unicorn·
View on SteamBuyChecking stores…

S.E.M.I. is a single-player and co-op action platformer with puzzle elements. Play as patients of an unusual clinic, take experimental drugs, interfere with each other, and be ready for chaos and unpredictable side effects!

Top matches

Match strength key:80+65+50+<50
Finding similar games…

About S.E.M.I. – Side Effects May Include...

S.E.M.I. – Side Effects May Include... video 1

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here, you and up to 3 of your brainless loyal friends play as patients, fighting staff and other patients while stumbling into all sorts of unexpected situations. Brawls, side-effect pills, and brutal platforming will absolutely challenge your clumsy friends’ hands sense of teamwork. Expect obstacles, puzzles, deadly traps, and rooms where a single wrong move can knock out the entire squad.

S.E.M.I. – Side Effects May Include... video 2S.E.M.I. – Side Effects May Include... video 3

Communicate in voice chat and arrange sabotage help your friends pass through rooms, get out of traps and fight with opponents! In your arsenal: close combat, physics, amazing abilities and ... imagination!

S.E.M.I. – Side Effects May Include... video 4S.E.M.I. – Side Effects May Include... video 5

Take pills and get abilities:

Bipolar force is an invulnerable monster, then a helpless rag!
Laser astigmatism — two sights, one laser… Where will he shoot?
Stendhal syndrome — are you looking at a painting? Now you're hysterical and destroying everything around you!
Alice's syndrome is either tiny or gigantic — have time to adjust!
S.E.M.I. – Side Effects May Include... video 6S.E.M.I. – Side Effects May Include... video 7

Madness is near! You and your friends can go crazy and start running, jumping and fighting, and your abilities will become uncontrollable. Do you want to take back control? Take the pills :)

S.E.M.I. – Side Effects May Include... video 8S.E.M.I. – Side Effects May Include... video 9

Locations are randomly generated from rooms with changing gravity, traps, moving walls, and other "pleasant" surprises.

S.E.M.I. – Side Effects May Include... video 10S.E.M.I. – Side Effects May Include... video 11

After a successful escape, you will receive a medical report: "The patient was stable until he started hitting the guards with a bottle. Diagnosis: Overmotivation" or something worse!

S.E.M.I. – Side Effects May Include... video 12S.E.M.I. – Side Effects May Include... video 13

Unlock new costumes and decorations. Let each new escape be more stylish than the previous one!

S.E.M.I. – Side Effects May Include... video 14

Will you and your friends be able to escape... or at least not go crazy?

Welcome to the mental hospital! Here, your abilities are a lottery, and your friends can be the most dangerous opponents!

Steam data © 2026 Valve Corporation. Trademarks are property of their respective owners.

All matches

Similar games to S.E.M.I. – Side Effects May Include...

Finding similar games…