67%Strong matchFinal Exam
84%1k84% positive reviews, Very Positive across 1k reviews·Beat 'em up · Local Co-Op
—







S.E.M.I. is a single-player and co-op action platformer with puzzle elements. Play as patients of an unusual clinic, take experimental drugs, interfere with each other, and be ready for chaos and unpredictable side effects!
S.E.M.I. – Side Effects May Include...
Steam
S.E.M.I. is a cooperative online game about escaping from a special clinic. Here, you and up to 3 of your brainless loyal friends play as patients, fighting staff and other patients while stumbling into all sorts of unexpected situations. Brawls, side-effect pills, and brutal platforming will absolutely challenge your clumsy friends’ hands sense of teamwork. Expect obstacles, puzzles, deadly traps, and rooms where a single wrong move can knock out the entire squad.


Communicate in voice chat and arrange sabotage help your friends pass through rooms, get out of traps and fight with opponents! In your arsenal: close combat, physics, amazing abilities and ... imagination!


Take pills and get abilities:


Madness is near! You and your friends can go crazy and start running, jumping and fighting, and your abilities will become uncontrollable. Do you want to take back control? Take the pills :)


Locations are randomly generated from rooms with changing gravity, traps, moving walls, and other "pleasant" surprises.


After a successful escape, you will receive a medical report: "The patient was stable until he started hitting the guards with a bottle. Diagnosis: Overmotivation" or something worse!


Unlock new costumes and decorations. Let each new escape be more stylish than the previous one!

Will you and your friends be able to escape... or at least not go crazy?
Welcome to the mental hospital! Here, your abilities are a lottery, and your friends can be the most dangerous opponents!
Steam data © 2026 Valve Corporation. Trademarks are property of their respective owners.
All matches
Finding similar games…
Final ExamShares Platformer · Online Co-op · Beat 'em up , adds Local Co-Op84% · 1k positive reviews67%Strong match—
Stuck TogetherShares Platformer · Physics · Online Co-op , adds Difficult89% · 211 positive reviews68%Strong match—
Shift HappensShares Platformer · Online Co-op · Funny , adds Local Co-Op79% · 3k positive reviews66%Strong match—
Evolve or DieShares Online Co-op · Action Roguelike · Co-op , adds Looter Shooter98% · 273 positive reviews64%Good match—
Risk of Rain 2Shares Online Co-op · Third Person · Action Roguelike , adds Third-Person Shooter94% · 353k positive reviews64%Good match—
Just Shapes & BeatsShares Online Co-op · Funny · Co-op , adds Rhythm98% · 22k positive reviews64%Good match—All matches
The best games like S.E.M.I. – Side Effects May Include... are Final Exam, Stuck Together, Shift Happens, Evolve or Die, and Risk of Rain 2.
Match on: filter matches for S.E.M.I. – Side Effects May Include... by tag
Filters all matches
65%+Strong matches
50%+Good matches